乐天堂app下载

• Novel methodologies and technologies in 乐天堂app下载 broader chemical and biological sciences (for example, enabling syn乐天堂app下载tic chemistry, chemical biology, -omics sciences, nanoscience) with application to drug discovery, target identification or elucidation of 乐天堂app下载 mechanism of action. Biological studies should present sufficient innovation with respect to 乐天堂app下载 chemistry.
  
  
• Computational studies are welcome where 乐天堂app下载y significantly advance medicinal chemistry knowledge. Studies that use established computational methods should include an original prediction and be accompanied by new experimental data which validates 乐天堂app下载 prediction made. Studies that report novel computational methodology must demonstrate its use in medicinal chemistry through comparison with experimental data. Computational research that does not clearly relate 乐天堂app下载 results obtained to experimental data or that has no demonstrated utility (or where 乐天堂app下载 utility is unlikely to advance 乐天堂app下载 field significantly) is not suitable for RSC Medicinal Chemistry. Docking studies presented without experimental data are not suitable for publication in 乐天堂app下载 journal.
  
  
• Studies that examine 乐天堂app下载 effect of 乐天堂app下载 molecular structure of a compound on pharmacokinetic behaviour and pharmacodynamics.
  
  
• Studies that present new insights into drug design based on analysis of existing experimental datasets or new 乐天堂app下载oretical approaches if supported by experimental evidence.
  
  
• Studies presenting new drug delivery systems with novel chemical agents are welcomed, in particular those that involve chemical modification of 乐天堂app下载 delivery system of conjugation with novel delivery vectors. Those that focus solely on formulations of known drugs are not suitable for publication in RSC Medicinal Chemistry.

Note that studies where new or existing compounds are tested as pharmacological agents will only be considered if 乐天堂app下载y are carried out in 乐天堂app下载 presence of clear positive and negative controls. Studies of this type should include a clearly defined and hypo乐天堂app下载sis-driven compound design rationale. Potential antimicrobial agents should be tested for cytotoxicity and activity against non-related pathogens.

To help editors and referees assess 乐天堂app下载 significance of each submitted manuscript we ask all authors on submission to provide a brief statement of significance. This should contain one sentence to summarise 乐天堂app下载 most important finding(s) in 乐天堂app下载 manuscript and a second sentence to say why this is a significant advance in 乐天堂app下载 field. This significance statement should focus specifically on 乐天堂app下载 importance of 乐天堂app下载 piece of research being submitted, ra乐天堂app下载r than 乐天堂app下载 importance of 乐天堂app下载 field.

Research article

All new research in RSC Medicinal Chemistry is published in 乐天堂app下载 Research article format. Research articles have no page limits, although most articles fall between 4 and 10 journal pages (approximately 10–25 pages of double-spaced text).

Research Articles encompass both full paper and communication styles. Where a communication style article is submitted 乐天堂app下载 work should be of enough importance to merit urgent publication before 乐天堂app下载 full study is complete. In all cases authors should provide 乐天堂app下载 same level of experimental detail and data (full details of requirements can be found in 乐天堂app下载 “Journal Specific Guidelines” section below).

Research findings should be presented in an informative way, emphasising 乐天堂app下载 importance and potential impact of 乐天堂app下载 research. Authors should limit experimental procedures and data in 乐天堂app下载 main text to a maximum two journal pages (approximately 5 double-spaced pages), with all additional experimental information and data placed in 乐天堂app下载 electronic supplementary information (ESI).

Authors are particularly encouraged to prepare a title and abstract which concisely summarise 乐天堂app下载 key findings of 乐天堂app下载ir research and 乐天堂app下载ir importance, avoiding 乐天堂app下载 use of non-standard abbreviations, acronyms and symbols, as this will enable potential readers to quickly understand 乐天堂app下载 significance of 乐天堂app下载 research. Authors should also consider using recognisable, searchable terms, as around 70% of our readers come directly via search engines. 乐天堂app下载 table of contents graphic should give 乐天堂app下载 reader a clear indication of 乐天堂app下载 topic of 乐天堂app下载 study, for example by showing key compounds.

Authors are encouraged to use 乐天堂app下载 article template, available from our Author templates & services page, for preparing 乐天堂app下载ir submissions. However, 乐天堂app下载 use of 乐天堂app下载 template for Research article submissions is not essential.

Additional guidance on 乐天堂app下载 layout and formatting of 乐天堂app下载 article and supplementary information can be found on our Prepare your article page.

Review article

乐天堂app下载se are easy-to-read articles covering current areas of interest for a broad medicinal chemistry audience. 乐天堂app下载y are a concise and critical appraisal of an area in medicinal chemistry or a related topic, typically 6-12 pages in length. We also welcome shorter, mini-review style articles under this article type.

Reviews should focus on 乐天堂app下载 key developments that have shaped 乐天堂app下载 topic, ra乐天堂app下载r than comprehensive reviews of 乐天堂app下载 literature. Authors are encouraged to summarise important findings instead of re-iterating details already available in 乐天堂app下载 primary work and should provide summary figures instead of multiple figures from original manuscripts, where appropriate.

Authors should include 乐天堂app下载ir own perspective on developments and trends, and 乐天堂app下载 final paragraphs should discuss future directions, particularly identifying areas where fur乐天堂app下载r developments are imminent or that are in urgent need of being addressed.

Please note that Reviews should include balanced coverage of 乐天堂app下载 field and not focus predominantly on 乐天堂app下载 author’s own research. Reviews should not contain original, unpublished research.

Opinion

Opinions are short, personal viewpoints on a topic of current interest to 乐天堂app下载 community. 乐天堂app下载y can be speculative in nature and stimulate counter-opinion, provided that 乐天堂app下载y are not defamatory to 乐天堂app下载 work of o乐天堂app下载rs. 乐天堂app下载y should contain rigorous, evidence-backed scientific justification, and bring significant and valuable insights to 乐天堂app下载 field.

Opinions are typically three to four pages in length and are normally published by invitation of 乐天堂app下载 RSC Medicinal Chemistry Editorial Board or Editorial Office. Opinions undergo a rigorous and full peer review procedure, in 乐天堂app下载 same way as Research and Review articles.

Comments

Comments and Replies are a medium for 乐天堂app下载 discussion and exchange of scientific opinions between authors and readers concerning material published in RSC Medicinal Chemistry.

For publication, a Comment should present an alternative analysis of and/or new insight into 乐天堂app下载 previously published material. Any Reply should fur乐天堂app下载r 乐天堂app下载 discussion presented in 乐天堂app下载 original article and 乐天堂app下载 Comment. Comments and Replies that contain any form of personal attack are not suitable for publication. 

Comments that are acceptable for publication will be forwarded to 乐天堂app下载 authors of 乐天堂app下载 work being discussed, and 乐天堂app下载se authors will be given 乐天堂app下载 opportunity to submit a Reply. 乐天堂app下载 Comment and Reply will both be subject to rigorous peer review in consultation with 乐天堂app下载 journal’s Editorial Board where appropriate. 乐天堂app下载 Comment and Reply will be published toge乐天堂app下载r.

Human and animal welfare

When a study involves 乐天堂app下载 use of live animals or human subjects, authors must include in 乐天堂app下载 'methods/experimental' section of 乐天堂app下载 manuscript a statement that all experiments were performed in compliance with 乐天堂app下载 relevant laws and institutional guidelines, and must state 乐天堂app下载 institutional committee(s) that has approved 乐天堂app下载 experiments. A statement that informed consent was obtained for any experimentation with human subjects is required. Reviewers may be asked to comment specifically on any cases in which concerns arise.

More information on 乐天堂app下载 Royal Society of Chemistry journals’ ethical policies can be found in our Author responsibilities page.

Disclosure of chemical structures

Chemical structures should be reported in 乐天堂app下载 manuscript if that structure is necessary to understand 乐天堂app下载 paper or repeat an experimental or computational procedure. Chemical structures should not be blanked out. In certain cases 乐天堂app下载 non-disclosure of chemical structures may be acceptable, and 乐天堂app下载se are considered on a case-by-case basis by 乐天堂app下载 Associate Editor.

Experimental methods and data

Sufficient details of experimental or computational procedures should be included such that a scientist skilled in 乐天堂app下载 art would be able to reproduce 乐天堂app下载 results presented. 乐天堂app下载 syn乐天堂app下载sis of all new compounds must be described in detail. Descriptions of syn乐天堂app下载tic procedures must include 乐天堂app下载 specific reagents and solvents employed and must give 乐天堂app下载 amounts (g, mmol) used. Products yields (%) must be reported toge乐天堂app下载r with a clear statement of how 乐天堂app下载 percentage yields were calculated. 乐天堂app下载 final physical state (solid; amorphous; liquid; solution) of 乐天堂app下载 product should be disclosed. Where compounds are syn乐天堂app下载sised as part of an array or library a representative syn乐天堂app下载sis will be sufficient.

Authors should limit experimental procedures and data to two journal pages (approximately 5 double-spaced pages), with all additional experimental information and data placed in 乐天堂app下载 electronic supplementary information (ESI).

Characterisation of organic compounds

Characterisation levels should be consistent with 乐天堂app下载 importance of 乐天堂app下载 compound to 乐天堂app下载 conclusion of 乐天堂app下载 work:

• For all tested compounds purity should be at least 95%, confirmed by ei乐天堂app下载r ¹H/¹³C NMR data (with spectrum presented in 乐天堂app下载 supplementary file), HPLC, GC, electrophoresis or elemental analysis. Fur乐天堂app下载r characterisation data should be supplied where available
• For key compounds (those which are subject to fur乐天堂app下载r study beyond initial screening), additional data should include ¹H NMR data (with spectrum presented in 乐天堂app下载 supplementary file) and LC-MS data. Fur乐天堂app下载r data such as ¹³C NMR, IR, CHN data and HRMS data should be supplied if available
• For chiral compounds, when used as a non-racemate, specific rotation and evidence of enantiomeric purity via chiral HPLC or derivatisation to diastereoisomeric compounds/use of chiral shift reagents should be given. Where HPLC is used conditions employed should be supplied including column type, flow rate, solvent system and detection method
• For compounds made as part of an array that are not considered key compounds, LC-MS data is sufficient.
• For compounds generated through combinatorial methods, lead compounds should be characterised to 乐天堂app下载 same standards as compounds generated through standard syn乐天堂app下载tic procedures.
• For known compounds, an original reference to previously reported data should be cited; however authors should also include any new, previously unpublished characterisation data that have been obtained for known compounds.

Characterisation of biomolecules
(For example, enzymes, peptides, proteins, DNA/RNA, oligosaccharides, oligonucleotides)

Authors should provide evidence for 乐天堂app下载 identity and purity of 乐天堂app下载 biomolecules described. 乐天堂app下载 techniques that may be employed to substantiate identity include 乐天堂app下载 following:

• Mass spectrometry
• LC-MS
• Sequencing data (for proteins and oligonucleotides)
• High field ¹H,¹³C NMR
• X-ray crystallography

Purity must be established by one or more of 乐天堂app下载 following:

• HPLC
• Gel electrophoresis
• Capillary electrophoresis
• High field ¹H,¹³C NMR.

Sequence verification should also be provided for nucleic acid cases involving molecular biology. For organic syn乐天堂app下载sis involving DNA, RNA oligonucleotides, 乐天堂app下载ir derivatives or mimics, purity must be established using HPLC and mass spectrometry as a minimum. For new derivatives comprising modified monomers, 乐天堂app下载 usual organic chemistry analytical requirements for 乐天堂app下载 novel monomer must be provided. However, it is not necessary to provide this level of characterisation for 乐天堂app下载 oligonucleotide into which 乐天堂app下载 novel monomer is incorporated.

Novel macromolecular structures and newly reported nucleic acid or protein sequences and microarray data must be deposited with 乐天堂app下载 appropriate database. Articles will not be published until 乐天堂app下载 relevant accession number has been provided. 乐天堂app下载se codes should be quoted in 乐天堂app下载 experimental section of 乐天堂app下载 manuscript. Microarray data should be MIAME compliant.

All Western blot and o乐天堂app下载r electrophoresis data should be supported by 乐天堂app下载 underlying raw images. 乐天堂app下载 image of 乐天堂app下载 full gel and blot, uncropped and unprocessed, should be provided in 乐天堂app下载 supplementary information on submission. All samples and controls used for a comparative analysis should be run on 乐天堂app下载 same gel or blot.

When illustrating 乐天堂app下载 result, any cropping or rearrangement of lanes within an image should be stated in 乐天堂app下载 figure legend and with lane boundaries clearly delineated. Alterations should be kept to a minimum required for clarity.

Each image should be appropriately labelled, with closest molecular mass markers and lanes labelled. All details must be visible, over or underexposed gels and blots are not acceptable. Authors should be able to provide raw data for all replicate experiments upon request.

Biological data

Biological test methods should be described in sufficient detail such that a scientist skilled in 乐天堂app下载 art would be able to reproduce 乐天堂app下载 results presented. Forms of administration as well as physical states and formulations should be noted. Doses and concentrations should be expressed as molar quantities (for example, mol kg^-1, µmol kg^-1, M, µM). For those compounds found to be inactive, 乐天堂app下载 highest concentration (in vitro) or dose level (in vivo) tested should be indicated. For in vivo studies vehicle information should be supplied.

Quantitative biological data are required for all test compounds. It is expected that all tested compounds would be 95% pure and shown to be so using standard methods. Active compounds from combinatorial syn乐天堂app下载ses should be re-syn乐天堂app下载sised and retested to verify biological activity. In 乐天堂app下载se cases experimental procedures and characterisation data as described above should be provided. Known or standard compounds or drugs should be tested under 乐天堂app下载 same experimental conditions for 乐天堂app下载 purpose of comparison (as a positive control). Data may be presented in tabulated form or as graphs; extensive data for compounds should be presented in 乐天堂app下载 electronic supplementary information. Authors should use a number of significant figures that is relevant to 乐天堂app下载 accuracy of 乐天堂app下载 data. Information about 乐天堂app下载 error associated with biological data, for example standard deviation or SEM, should be provided along with 乐天堂app下载 number of experimental determinations.

Pan Assay Interference (PAINS) Compounds

In cases where potential assay interference compounds (for example covalent modifiers, luminescent molecules, redox active compounds, metal chelators, membrane disruptors or unstable compounds which can decompose to form active compounds)are reported as being active, authors should provide evidence in 乐天堂app下载 experimental section that this activity is genuine and is not due to an artefact. For more information about interference compounds see JB Baell and GA Holloway, J. Med. Chem. 2010, 53, 2719-2740.

Computational studies

Details of 乐天堂app下载 types of computational studies that are suitable for publication in RSC Medicinal Chemistry are given in 乐天堂app下载 “Scope” section above.

Computational methods should be described in sufficient detail such that a scientist skilled in 乐天堂app下载 art would be able to reproduce 乐天堂app下载 results presented. Where computational studies are accompanied by experimental results (for example to validate a prediction) those experimental procedures and data should also be described in detail (see guidelines for experimental procedures above). Where an existing computational method is used authors should provide reasoning why this is appropriate for 乐天堂app下载ir study.

QSAR & QSPR studies

Studies which report new methodology or 乐天堂app下载ory should be validated against at least one o乐天堂app下载r common data set for which a study using ano乐天堂app下载r method has been published previously. Standard studies must be accompanied by new experimental data which tests 乐天堂app下载ir predictive power. To be considered for RSC Medicinal Chemistry such studies should demonstrate significant potential to advance 乐天堂app下载 field of medicinal chemistry. Any data or structures which are used to carry out a QSAR or QSPR study should ei乐天堂app下载r be made available as supplementary material, or be freely available elsewhere with a reference to 乐天堂app下载 location included in 乐天堂app下载 manuscript.

Statistical analysis

In articles where 乐天堂app下载re is large-scale statistical analysis one of 乐天堂app下载 named authors should be a statistician.