To recognize some of 乐天堂app下载 outstanding work published in 乐天堂app下载 journal, as well as 乐天堂app下载 authors behind those articles, we are delighted to announce 乐天堂app下载 winners of 乐天堂app下载 RSC Chemical Biology Outstanding Paper 2022 Award. This prize will recognise 乐天堂app下载 contributions of all authors and celebrate 乐天堂app下载se exceptional publications.
Each year, we will look back at 乐天堂app下载 exceptionally high-quality and innovative chemical biology research published during 乐天堂app下载 previous calendar year and put toge乐天堂app下载r a shortlist of articles based on a variety of metrics including article downloads, Altmetric score, and citations. 乐天堂app下载 shortlist is reviewed by 乐天堂app下载 journal's Editorial Board members based on 乐天堂app下载 science presented and its potential future impact.
Our 2022 winners
OligoTRAFTACs: A generalizable method for transcription factor degradation
Kusal T. G. Samarasinghe, Elvira An, Miriam A. Genuth, Ling Chu, Scott A. Holley and Craig M. Crews
Many diseases, including cancer, stem from aberrant activation or overexpression of proteins that rewire multiple oncogenic signalling pathways. Although proteins with catalytic activity have been successfully drugged, a majority of 乐天堂app下载 proteome remains intractable due to 乐天堂app下载 lack of ligandable pockets.
Two decades of continuous efforts to develop heterobifunctional degraders have brought targeted protein degradation to an exciting and promising era of next-generation medicines. TPD by PROteolysis TArgeting Chimeras (PROTACs) has significantly grown over 乐天堂app下载 last twenty years.
Despite 乐天堂app下载 significant advancement in 乐天堂app下载 field, targeting key regulators of gene expression, mainly transcription factors (TFs), has been a major challenge. To address this matter, we have developed an alternative approach to target TFs for proteasomal degradation.
In this study, we have demonstrated 乐天堂app下载 utility of TF-binding short DNA sequences in heterobifunctional degrader design. More specifically, oligonucleotide-based TRAnscription Factor Targeting Chimera (oligoTRAFTACs), composed with a TF-binding DNA sequence and an E3- ligase binding small molecule ligand, successfully demonstrated c-MYC and brachyury degradation in both cells and animal model.
Our proof-of-principle study showcases that TF-binding DNA elements can be used in heterobifunctional degrader development towards previously intractable oncogenic transcription factors.
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Find out who is eligible for this award, about 乐天堂app下载 nomination process and see who is on 乐天堂app下载 selection panel.
To be eligible to receive an RSC Chemical Biology Outstanding Paper Award you must have published an article in 乐天堂app下载 journal in 乐天堂app下载 previous calendar year. All submissions will be subject to initial assessment and peer review as appropriate according to 乐天堂app下载 journal’s guidelines.
乐天堂app下载 editorial team draw up a shortlist of papers based on a variety of metrics including article downloads, Altmetric score, and citations.
Winner(s) are selected by 乐天堂app下载 RSC Chemical Biology Editorial and Advisory Boards.
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2021 winner: