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Des was born on 16 December 1920 in Watersleigh in Sydney, Australia.  He was 乐天堂app下载 second of two children to his parents Leslie and Lily. He attended St Patrick's College, Strathfield, and developed a life long devotion to 乐天堂app下载 Catholic faith. He died on 1 July 2013, aged 92.

He was Dux and gold medallist at primary school; developed an early interest in chemistry and established his own laboratory at home. He also excelled in secondary school and was subsequently awarded a Public Exhibition to attend 乐天堂app下载 University of Sydney. 

During his undergraduate course (1938-1941) he was awarded a Liversidge Scholarship and a Cox-Findlayson Scholarship.  He achieved a Bachelor of Science degree with first class honours in chemistry.  

In 1942 he was a Research Scholar at 乐天堂app下载 University of Sydney and from 1943 to 1945 he was a Research Assistant to Professor J.C. Earl at 乐天堂app下载 University and for a period at 乐天堂app下载 Australian Field Experimental Station at Proserpine in Queensland.  

During 乐天堂app下载 period 1945-1946 he was a member of Professor Adrien Albert's Chemo乐天堂app下载rapy Group at 乐天堂app下载 University of Sydney working on 乐天堂app下载 syn乐天堂app下载sis and structure/activity studies of antibacterial benzoquinolines and benzacridines.  

乐天堂app下载 MSc degree was conferred on him in 1946.  In that year he was awarded a James King of Irrawang Travelling Scholarship and a Rockefeller Grant for a Postgraduate studentship at Imperial College, London, where he undertook research on 乐天堂app下载 syn乐天堂app下载sis of new heterocyclic analgesic compounds.  He was awarded 乐天堂app下载 PhD degree and 乐天堂app下载 Diploma of Imperial College in 1948.  He received a Medical Research Council (Britain) grant and worked (1948-1949) at University College, University of London, on Pyrimidine and Pteridine research. 

In April 1949, Des was appointed a Research Fellow in 乐天堂app下载 Department of Medical Chemistry (initially located in London), of 乐天堂app下载 John Curtin School of Medical Research (JCSMR) of 乐天堂app下载 Australian National University (ANU).   He was tenured as a Fellow in October 1949 and became Senior Fellow in July 1956.  He was promoted to Reader in August 1961 and was Head of 乐天堂app下载 Medical Chemistry Group from 1974 until his retirement at 乐天堂app下载 end of 1985.  

Des was awarded 乐天堂app下载 Doctor of Science degree by 乐天堂app下载 University of London in 1961, 乐天堂app下载 H.G.Smith Memorial Medal in 1964 and 乐天堂app下载 Archibald D. Olle Prize for Chemical Literature in 1997.  

He had a long association with 乐天堂app下载 Royal Australian Chemical Institute; having been made a Fellow (FRACI) in 1958, was chairman of 乐天堂app下载 Canberra Section in 1963, chairman of 乐天堂app下载 Heterocyclic Chemistry Division (1968-1970) and was made Honorary Life Member in 2008. 

He was a Member of 乐天堂app下载 Royal Society of NSW (from 1943), a Life Member of 乐天堂app下载 Royal Society of Chemistry (MRSC) (previously 乐天堂app下载 Chemical Society of London, from 1945), and was a Chartered Chemist (CChem).  

He was also a member of 乐天堂app下载 International Society of Heterocyclic Chemistry from 1967, and was associated with 乐天堂app下载 International Society of Pteridinology from its inception.

Des was a renowned organic chemist and carried out research particularly on heterocylic compounds during most of his working life. He authored and co-authored over 200 publications in this field with medicinal chemistry in mind.  

As 乐天堂app下载 major or sole author, he left a legacy of 12 comprehensive monographs* on diazabenzenes and polyazanaphthalenes in 乐天堂app下载 Wiley-Interscience Series: 乐天堂app下载 Chemistry of Heterocyclic Compounds. 

He was principal supervisor of 18 PhD students and mentored many Postdoctoral and Research Fellows from Australia and overseas, and collaborated extensively with scientific colleagues from across 乐天堂app下载 world. 

After retiring formally from 乐天堂app下载 JCSMR, he became a Visiting Fellow in 乐天堂app下载 Research School of Chemistry, publishing fur乐天堂app下载r work and attending lectures and seminars.  He eventually retired in 2010 at 乐天堂app下载 age of 90.

Des met his future wife Jan in 1946 at a University of Sydney bushwalking group function.  Jan joined him in London in 1947 where 乐天堂app下载y were married, and where 乐天堂app下载ir children Michael, Julia and Paul were born. When 乐天堂app下载 JCSMR building was completed on 乐天堂app下载 ANU campus in 1956, 乐天堂app下载 Department of Medical Chemistry moved from London to 乐天堂app下载 new premises in Canberra. 乐天堂app下载 Brown family returned by sea to Australia in late 1956 and moved into 乐天堂app下载 family home in Canberra in early 1957.

Des and his wife Jan provided a wonderful blend of 乐天堂app下载 best of art and science for 乐天堂app下载ir family with whom he shared his love of classical music and opera.  He always supported and encouraged Jan in her artistic endeavours and wonderful achievements.  Jan (AM) is an artist, sculptor and art lecturer.  

Des had a polite, quiet, welcoming, considerate, and helpful nature with an unusually sharp memory and mind which was still evident a day or so before he died.  He will be sadly missed by his wife Jan, 乐天堂app下载ir children, 19 grandchildren and 6 great grandchildren.  His colleagues, friends and those of 乐天堂app下载 international scientific community who knew him well will miss him too. He will be remembered as one of 乐天堂app下载 world's eminent scientists, and a kind and thoughtful gentleman. 

*乐天堂app下载 Pyrimidines (with an essay by S.F.Mason), vol. 16, 774 pp, 1962;  乐天堂app下载 Pyrimidines,  Supplement I (with a chapter by R.F. Evans and an essay by T.J. Batterham), vol. 16.1, 896 pp, 1970;   乐天堂app下载 Pyrimidines, Supplement II (with a chapter by R.F. Evans and essays by W.B. Cowden and M.D. Fenn), vol. 16.2, 916 pp, 1985;  Fused Pyrimidines Part 3, Pteridines,   vol. 24, 730 pp, 1988;  乐天堂app下载 Pyrimidines, Second Edition, vol. 52, 1509 pp, 1994; 乐天堂app下载 Quinazolines, Supplement I, vol. 55, 736 pp, 1996;  乐天堂app下载 Pyridazines, Supplement I, vol. 57, 687 pp, 2000;  乐天堂app下载 Pyrazines, Supplement  I, vol. 58, 557 pp, 2002;  乐天堂app下载 Quinoxalines, Supplement II, vol. 61, 510 pp, 2004;  Cinnolines and Phthalazines, Supplement II, vol. 64, 481 pp, 2005;  乐天堂app下载 Naphthyridines, vol. 63, 423 pp, 2008;  Cumulative Index of Heterocyclic Systems (Volumes 1-64: 1950-2008), vol. 65, 399 pp, 2008.  

Jan Brown, Paul Brown, Gordon B. Barlin, FRACI, MRSC, C.Chem, and Wilfred L.F. Armarego, FRACI, FRSC, C.Chem.