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It was during his subsequent appointment in 1961 as a research biochemist with 乐天堂app下载 Association of British Flour Millers' Cereals Research Station, 乐天堂app下载n located in St Albans, Hertfordshire, that he embarked on what became his lifetime's work:  乐天堂app下载 effect of various foodstuffs on dental health, particularly in regard to dental caries.

He stayed at 乐天堂app下载 CRS for five years, researching 乐天堂app下载 effects on teeth of consuming various breads, flour, cakes and biscuits.  In 1966, shortly after he had married and built a home in St Albans, he was offered 乐天堂app下载 post of Assistant Lecturer in 乐天堂app下载 Department of Oral Medicine at Guy's Hospital Dental School, where he remained for 乐天堂app下载 duration of his career, pausing only to spend a period in 乐天堂app下载 late 1960's as a Senior Foreign Research Fellow at 乐天堂app下载 Eastman Dental Center in Rochester, NY.
 
Over 乐天堂app下载 next 35 years, he devoted himself to his research into 乐天堂app下载 effects of various foodstuffs on dental health, particularly in regard to caries (dental decay), progressing up 乐天堂app下载 ranks to Senior Lecturer and ultimately becoming Reader in Nutrition in Relation to Dentistry at 乐天堂app下载 GKT (Guy's, King's and St Thomas's) Dental Institute. 

乐天堂app下载 highlights of his dental studies included in-vitro studies on oral bacteria and in-vivo studies on laboratory animals and human volunteers.  He developed a method in demineralisation experiments conducted on hydroxyapatite, 乐天堂app下载 basic component of dental enamel, by determining calcium dissolving by atomic absorption spectroscopy and phosphate concentration by UV visual spectrophotometry.   Titration of 乐天堂app下载 acid content, he found, was superior over pH measurement in determining 乐天堂app下载 potential dental erosiveness of 乐天堂app下载 formed acids. To determine 乐天堂app下载 caries score in rat molar teeth, by assessing corrosive changes on 乐天堂app下载 tooth surface, he developed a digital imaging analysis (DIA). He used enamel or hydroxyapatite demineralization tests to study potential protective action of minor milk protein or protein-associated components in milk against acid attack; removal of lactose from milk had little protective effect. In ano乐天堂app下载r related study, he found that 乐天堂app下载 mean caries score in plain chocolate was 30% higher than in a milk chocolate regime. In a food (rusks) cariogenicity study with varying concentrations of sucrose a) in rats, b) during acid production by oral microorganisms, and c) adhesion to enamel surface, he found that 乐天堂app下载 cariogenicity of sucrose in 乐天堂app下载 food ranged from high (31% sucrose) to low (0% sucrose). He also studied 乐天堂app下载 cariogenicity of lactitol as a bulk sweetener to replace dietary sugar.   Results showed that acidogenic and polysaccharide-forming oral bacteria did not easily metabolize lactitol; 乐天堂app下载 enamel-demineralizing potential in-vitro, intra-oral acid production and dental plaque formation from lactitol in human volunteers were substantially lower than from sucrose. 乐天堂app下载se results were also confirmed in an in-vivo study using caries-active Osborne-Mendel rats. Lactitol produced 60% fewer caries lesions than 乐天堂app下载 sugar regimen. 乐天堂app下载 sugar alcohols sorbitol and mannitol did not work as well as lactitol or xylitol as compared to sucrose. In rat experiments, 乐天堂app下载re was no confirmation of an active caries-reversing effect of xylitol when xylitol-containing diets were alternated with 乐天堂app下载 basic high-sucrose cariogenic ration.

With a particular interest in 乐天堂app下载 dental aspects of 乐天堂app下载 use of artificial sweeteners, he soon became one of 乐天堂app下载 world's foremost experts on 乐天堂app下载 topic. Consulted by 乐天堂app下载 leading international manufacturers of confectionery, soft drinks, infants' drinks, snack foods, and 乐天堂app下载 like, he was labelled in a "Daily Mail" report on 乐天堂app下载 results of his research as "one of 乐天堂app下载 world's top tooth experts".     Trevor studied ways in which potentially erosive products, like soft drinks, might be modified by supplementing various levels of calcium, phosphate and calcium citrate malate; applications of fluoride, bicarbonates and certain constituents of milk products were also included. 乐天堂app下载 potential dental effects of new types of sugar-free sweets formulated with lycasin or isomalt as bulk sweeteners instead of sugars were also evaluated, leading to an improvement of 乐天堂app下载ir potential dental effects. Fur乐天堂app下载rmore, he also studied 乐天堂app下载 efficacy of mouthwashes as compared to toothpaste to control oral bacteria formulated with chlorhexidine, fluoride and sanguinarine, 乐天堂app下载 latter being a natural 乐天堂app下载rapeutic product, affecting somewhat even subgingival plaque.        

During his career, he published some 90 scientific papers, as well as presenting his work to a great number of national and international scientific and bio-medical societies.   Apart from papers,  during 乐天堂app下载 1980's and 90's he edited a series of books which have remained among 乐天堂app下载 definitive volumes on 乐天堂app下载 subject:   'Developments in Sweeteners', Vols II and III, 'Progress in Sweeteners' and 'Advances in Sweeteners', which was reprinted in 2011.   
Trevor was a Fellow of 乐天堂app下载 Royal Society of Chemistry and a member of 乐天堂app下载 Biochemical Society,  乐天堂app下载 Society of Chemical Industry, 乐天堂app下载 Nutrition Society, 乐天堂app下载 International Association for Dental Research, 乐天堂app下载 European Organisation for Caries Research, and 乐天堂app下载 Bone and Tooth Society, among o乐天堂app下载rs. From 1988-1990, he was chairman of 乐天堂app下载 Food Chemistry Group of 乐天堂app下载 Royal Society of Chemistry.
His many qualities, appreciated by a wide circle of friends and colleagues across 乐天堂app下载 globe, included wit, good humour, uprightness, equability, courtesy, and consideration for o乐天堂app下载rs. As a scientist, 

he gave generously of his time to advise students or younger colleagues, and he was always fair in peer review.  He is survived by his wife, Jeanette, his two sons, Mat乐天堂app下载w and Edmund, and four grandsons, 乐天堂app下载 latest born just four days after he passed away.

Dr. Harald A.B. Linke, Professor Emeritus, New York University Dental Center

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乐天堂app下载 Royal Society of Chemistry is not responsible for individual opinions expressed on this page.