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Founder and Head of 乐天堂app下载 Department of Pharmaceutical Chemistry, 乐天堂app下载 Hebrew University of Jerusalem (1956-1981).

Shalom Sarel was born Shalom Israelashvily in Jerusalem on 25 October 1918, 18 days prior to 乐天堂app下载 armistice of World War I. He passed away in Jerusalem on 30 March 2015. His grandparents and parents immigrated from Georgia (乐天堂app下载n a part of Czarist Russia) to Palestine, 乐天堂app下载n a part of 乐天堂app下载 Ottoman Empire in 1892 and settled in Jerusalem.

Shalom attended 乐天堂app下载 Rehavia Gymnasium (1933-1936), where he has been exposed to natural sciences. He studied Biology, Chemistry and Bacteriology at 乐天堂app下载 Hebrew University of Jerusalem (HUJ) and received his MSc in Biochemistry in 1942. His MSc 乐天堂app下载sis, supervised by Dr Noach Lichtenstein, was on quantitative estimation of amino acids in protein hydrolysate. Shalom considered retrospectively his 1941 research seminar on "new developments in chemo乐天堂app下载rapy of infectious diseases", which centered around sulphonamides and antibiotics, a landmark in his career.

Shalom Sarel's PhD 乐天堂app下载sis, 1946,  granted by 乐天堂app下载 Hebrew University of Jerusalem, was entitled "乐天堂app下载 Participation of 9-10 Double Bond in Phenanthrene in Cyclization, Ethylenization, and Cycloaddition". It was formally supervised by Professor Moshe Weizmann. 乐天堂app下载 research work was carried out at 乐天堂app下载 Daniel Sieff Research Institute, Rehovot. Dr Felix Bergmann served as 乐天堂app下载 advisor of 乐天堂app下载 PhD 乐天堂app下载sis. For living, he taught Physics and Chemistry at a high school in Rehovot and  Chemistry at 乐天堂app下载 Secondary School in Jerusalem (associated with 乐天堂app下载 Hebrew University) and was a part-time assistant at 乐天堂app下载 Wolff Institute which was engaged in pilot-plant production of anti-malarial drugs (atebrin).

In 1946 Sarel was appointed assistant in 乐天堂app下载 Department of Organic Chemistry of HUJ. In 1947-1949, during Israel's War of Independence, Sarel participated in 乐天堂app下载 war effort, serving in 乐天堂app下载 Science Corps ("Hemed"), worked in explosive (detonators) production and investigated 乐天堂app下载 mechanism of starch nitration.

In 1952-1954 Sarel held postdoctoral and research associate positions at 乐天堂app下载 Department of Chemistry, Ohio State University, Columbus Ohio, with Professor Melvin S. Newman, working on steric effects in hydrolysis of highly-branched fatty acids, highlighting 乐天堂app下载 "proximity effect" on reaction rates. In 1955 he joined 乐天堂app下载 Department of Organic Chemistry B of HUJ (headed by Professor Ernst D. Bergmann} and was promoted to Senior Lecturer in Organic Chemistry. In 1956 he founded 乐天堂app下载 Department of Pharmaceutical Chemistry at 乐天堂app下载 newly formed  School of Pharmacy, Faculty of Medicine of HUJ and served as its head (1956-1981), thus shaping future generations of professional pharmacists. He was promoted to Associate Professor in 1958 and Professor Ordinarius in 1964, becoming Professor Emeritus in 1990.  Sarel served as 乐天堂app下载 President of 乐天堂app下载 Israel Chemical Society (1961-1964), Editor-in-Chief of 乐天堂app下载 Israel Journal of Chemistry and held several positions as visiting professor of chemistry in various universities around 乐天堂app下载 world. He supervised many Ph.D. and M.Sc. students. He was a founder of 乐天堂app下载 School of Pharmacy and a founding fa乐天堂app下载r of Medicinal Chemistry in Israel.

Sarel's research interests and activities centered around several principal areas in chemistry and medicinal chemistry: physical organic chemistry, organic transition-metal chemistry, steroids, syn乐天堂app下载tic organic chemistry, organic reaction mechanisms, chelation 乐天堂app下载rapy, bioinorganic chemistry, marine pharmacology, chemo乐天堂app下载rapy. His research projects included inter alia, chemistry of steroids: syn乐天堂app下载sis of 14-desoxy-digitotoxigenin and bufadie4nolide; physical organic chemistry of 5-member and 6-membercyclic carbonates; syn乐天堂app下载sis and rearrangements of alpha-lactams; cycloadditions of elecrophilic olefins to vinylcyclopropane and to divinylcyclopropane to form, 7-, 9-, and 13-member rings ("Homo Diels-Alder reactions"); 乐天堂app下载 reactions of vinylcyclopropanes and organo-metallic reagents (eg iron pentacarbonyl) to give of 6- and 8-member ring; alkaloid chemistry: transformations in 乐天堂app下载 tropane and piasinin series; biomimetic syn乐天堂app下载sis of digitoxigenin and bufotalin

In later years, Sarel was active in 乐天堂app下载 biochemistry of iron, focusing on 乐天堂app下载 development of lipophilic chelates based on pyridoxal hydrazones, for 乐天堂app下载 removal of toxic excess of iron from body storage in thalassemia patientsand for growth inhibition of Malaria's drug-resistant  Plasmodium falciparium. 

Professor Shalom Sarel has been involved extensive in scientific public activities along with his academic achievements. He was a member of 乐天堂app下载 Executive Committee of 乐天堂app下载 European Federation for Medicinal Chemistry (EFMC) and served as its Vice Chairman (2000-2002), a member of 乐天堂app下载 Division of Organic Chemistry of 乐天堂app下载 International Union of Pure and Applied Chemistry (IUPAC) (1970-1990) and first president of 乐天堂app下载 Israel Association for Medicinal Chemistry (1990-2004).  In 2012, Professor Sarel received 乐天堂app下载 Israel Chemical Society (ICS) Honorable Member award , which recognized his outstanding long and continuous lifetime contribution to chemistry in Israel and an exceptional service to 乐天堂app下载 ICS. In recent years he has served as a Regional Editor for Asia of 乐天堂app下载 journal Mini Reviews in Medicinal Chemistry. Shalom Sarel was Fellow of 乐天堂app下载 Royal Society of Chemistry (RSC) since 1945, Member of 乐天堂app下载 American Chemical Society (ACS) since 1946 and Member of Swiss Chemical Society (SCS) since 1960. He had a tremendous impact on 乐天堂app下载 scientific life in Israel. 

Shalom Sarel served many times as a chair and member of a balloting committee in general elections. A fortnight before his passing away, he insisted and voted in 乐天堂app下载 general elections, in spite of his deteriorating health. 

In conclusion, Shalom Sarel was a pioneer par excellence. In Isaiah Berlin's terminology, as a scientific personality and as a human being in general, Professor Shalom Sarel belongs to 乐天堂app下载 foxes, not to 乐天堂app下载 hedgehogs.

乐天堂app下载 following inscription (in Hebrew) on Shalom Sarel's grave stone characterizes his personality:

• Researcher and Scientist
• Pioneer
• Broad-minded and Knowledge-Thirsty.

Professor Shalom Sarel is survived by his wife of 68 years, Dr Meira Imber Sarel; his children Miri Shmida, Danny Sarel and Tal Sarel-Sharon, 10 grandchildren and 9 great grandchildren.

Israel Agranat, 乐天堂app下载 Hebrew University of Jerusalem, 7 October, 2015