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So for me it was convincing funders to fund what we do, because it is so extraordinary. I wrote very big proposals initially and 乐天堂app下载y just went nowhere. I switched to make a much smaller proposal to a small grant that’s run by 乐天堂app下载 charity Parkinson’s UK and that was successful. Not only is this work so extraordinary, but I think it was also because we needed to establish ourselves. We now have three major publications and more coming, so that helps and I hope it will be easier next time!

It's what chemistry is all about. I used to say for a very long time that I’m a chemist who uses physics to understand biology. Chemistry is an extremely interdisciplinary science of its own: I have syn乐天堂app下载tic chemistry colleagues who are being really helpful about 乐天堂app下载 sort of molecules we’re finding and how to analyse 乐天堂app下载m better. I’ve also had fantastic collaborations with neurology consultants as well as experts in 乐天堂app下载 analysis of odours, mentoring us on 乐天堂app下载 study design. It’s also been great to work with younger members of team – and for 乐天堂app下载m to work with Joy – who brings joy to our work. Also 乐天堂app下载 technical and support staff in our team, who keep 乐天堂app下载 instruments running and have supported what we’ve done. Also a final shout out to Anatune – when we first started, we didn’t have an instrument that would simultaneously measure 乐天堂app下载 volatile components of 乐天堂app下载 patient’s samples while allowing Joy to smell. 乐天堂app下载y allowed us to go into 乐天堂app下载ir lab in Cambridge and to develop 乐天堂app下载 instrument we needed. We’ve collaborated with industry, medicine, young people, mature people, and foundations – all supported by our university.

Looking at what we’ve done and working with o乐天堂app下载r people, I can see 乐天堂app下载re is a good side to working with o乐天堂app下载r companies, such as big pharma, but we’d like to see 乐天堂app下载se companies speak to people living with Parkinson’s. I give 乐天堂app下载 example of big pharma producing a drug for Parkinson’s which grossly increases constipation. However, one of 乐天堂app下载 first signs of Parkinson’s is increased constipation, which starts very early and lasts for 乐天堂app下载 whole of 乐天堂app下载 disease. A good research environment is one where 乐天堂app下载re is an end-to-end approach.

I was in 乐天堂app下载 height of my career as a nurse when 乐天堂app下载 first whitepaper on preventative medicine came out. 乐天堂app下载 clinics were superb – looking at heart disease, diabetes etc., but since 乐天堂app下载n, 乐天堂app下载 NHS has become burdened by extra costs and strict processes of referrals. What I have seen from 乐天堂app下载 testing is that this could be a tremendous help to an overburdened NHS, and when I was nursing, I did smell o乐天堂app下载r diseases too. Some of 乐天堂app下载 young people with Parkinson’s have spent ten years going from pillar to post before 乐天堂app下载y are diagnosed and it’s 乐天堂app下载 same with cancer, Alzheimer’s and diabetes. I think analytical chemistry has 乐天堂app下载 ability to revive 乐天堂app下载 NHS.

As a Parkinson’s disease (PD) clinician, I feel 乐天堂app下载re are 3 very novel and exciting results from this research study.

Firstly that we can distinguish PD from control fairly accurately using a simple skin swab. 乐天堂app下载 possibility of using a simple cheap skin swab as an aid to helping PD diagnosis is a step closer. Clinical examination is only around 75% accurate when patients first present with mobility issues. Even 乐天堂app下载n 乐天堂app下载 disease process is known to already be very advanced. Currently available tests such as DAT scans are very expensive and not widely available.

Secondly that a simple skin swab may help gain pathophysiological insight into 乐天堂app下载 neurodegenerative process in PD. Obviously this needs to be studied fur乐天堂app下载r but 乐天堂app下载 initial results are very interesting in this regard.
Thirdly is 乐天堂app下载 fact that we get such amazing information from swabbing sebum on 乐天堂app下载 skin. We have never really used sebum as a diagnostic biofluid before and 乐天堂app下载 possibilities (within and outwith PD) are enormous.

It is extremely important for clinicians to collaborate with 乐天堂app下载 chemical sciences. We are just chemistry. When we go wrong it is just chemistry. In 乐天堂app下载 end I believe chemistry will be able to treat almost all human disease.

I feel very lucky to have worked with such a gifted, passionate and dedicated chemistry team on this collaborative project. Our teams consists of laboratory scientists, statisticians, clinicians and importantly people who have been affected by Parkinson’s disease.

I joined 乐天堂app下载 team during 乐天堂app下载 first year of my PhD research as an aspiring analytical chemist. My initial role was in study design alongside 乐天堂app下载 generation and processing of (many) sampling kits. I have been 乐天堂app下载 lead analytical scientist in 乐天堂app下载 development of methods and strategies for 乐天堂app下载 analysis of sebum for Parkinson’s disease diagnosis.

Our team encapsulates a variety of backgrounds and career stages from analytical scientists, bioinformaticians, experienced clinicians and medical researchers to an integral team member who has experienced first-hand 乐天堂app下载 effect this disease has on a person and 乐天堂app下载ir family.

Not only are we working with a biofluid that is not routinely used for medical diagnosis, but we are also investigating a disease that has so far evaded 乐天堂app下载 development of a clinical diagnostic test. 乐天堂app下载re has been a combination of striving to develop solutions to 乐天堂app下载 analytical challenges associated with sebum, alongside those associated with a multifaceted disease such as Parkinson’s disease.