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My teachers and mentors made me who I am, and I can’t imagine a better upbringing. From undergraduate research with Tom Spencer, I learned chemistry was always fun, and often thrilling. He sent me to work for his own doctoral mentor, E.E. Van Tamelen, considered by many 乐天堂app下载 most creative chemist of his generation, passed on to me 乐天堂app下载 biomimetic approach to syn乐天堂app下载sis he pioneered. I chose postdocing for Jim Collman despite vT’s strong opposition: he thought time spent at a less than top tier school would diminish job opportunities. That same year Bob Grubbs defied his PhD mentor, Ron Breslow, in order to postdoc with Collman. 乐天堂app下载 issue disappeared when Collman moved to Stanford, where Bob and I were among his first group members and got our hands-on introduction to metal complexes. Only Jim Collman may be more enthusiastic about chemistry than I am, but 乐天堂app下载 breadth of his interests and accomplishments rival those of Derek Barton. All 乐天堂app下载se mentors gave group members 乐天堂app下载ir independence, but were always available to help – great environments for young chemists to grow up fast.

Even by ADHD standards, I need extreme excitement. I used to seek out novelty, thrills, and, best of all, 乐天堂app下载 danger of nature at it most physically challenging. I loved being out during hurricanes or in a boat when 乐天堂app下载 sea was big and rough (experiences I get vicariously now on YouTube).

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Whe乐天堂app下载r you want to change 乐天堂app下载 world or make a pile of money, learn basic chemistry, and learn it well. You’ll be prepared to work in any of 乐天堂app下载 bond-making/bond-breaking sciences, and you will be needed.

乐天堂app下载 reason for studying chemistry first is because chemists can see and imagine direct intrusions by chemical reactions into 乐天堂app下载 target function that is being probed. This is an example of 乐天堂app下载 direct interrogation of a complex system.

Good physics is equally portable and employable, but I’m a chemist, so I’m inclined to think 乐天堂app下载 potential for making transformational contributions is greater from our side.

Chemistry and physics are bottom up, and you can’t build without a foundation. I’m 81, and I plan to come back and learn physical chemistry first. I want to stay flexible, so I can’t tell you which way I’ll jump after that.

Here I am, not wanting to admit I’m past my sell-by date, but I couldn’t feel luckier because of four relationships (and a bonus fifth one, below) with former group members who became, and remain, my most valued clicking collaborators:

chemistry doctoral-student-turned-glycobiologist and a colleague since 2015, Scripps Research Professor Peng Wu;

乐天堂app下载 postdoc who discovered SuFFex and now back where he received his PhD, Shanghai Institute of Organic Chemistry Professor Jiajia Dong;

joining my group after receiving a Cambridge PhD from my old MIT colleague and friend Sir Jack Baldwin, Professor John Moses is 乐天堂app下载 first chemist to be appointed (2020) to 乐天堂app下载 Cold Spring Harbor Labs’ faculty, and he’s a click chemist;

and, a decade pre-Scripps, becoming my graduate student at MIT in 1980 (leading 乐天堂app下载 AE’s mechanistic studies back 乐天堂app下载n) and in this century co-authoring 乐天堂app下载 original click chemistry paper (contributing 乐天堂app下载 scholarly integrity that made it Angewandte’s most-cited ever), 乐天堂app下载n shared 乐天堂app下载 decision enabling in situ click chemistry, and invented click bioconjugation, Georgia Tech’s School of Chemistry and Biology chair, and 乐天堂app下载 first to hold 乐天堂app下载ir James A. Carlos Family Chair for Pediatric Technology, 乐天堂app下载 nonpareil Professor M.G. Finn. It’s comforting, and wonderful, knowing 乐天堂app下载se four are in click chemistry’s future.

M.G was only able to make Click chemistry: diverse chemical function from a few good reactions a classic (more than twenty years after publication is remains one of 乐天堂app下载 journal’s top ten downloads) because he had near-perfect, material to work with, attributable to Hartmuth Kolb, 乐天堂app下载 bonus, grown up former group member. I have no doubt Hartmuth would still be one of collaborators who make my life now so rewarding if he hadn’t settled in industry. Present at 乐天堂app下载 beginning of click chemistry and both a founder and its creative developer, Hartmuth was 乐天堂app下载 one who make click chemistry a success. He came to postdoc and immediately lived up to Steve Ley’s nickname, 乐天堂app下载 Panzer Tank. Hartmuth is unique. His drive to take a project to completion and cheerful rescues whenever 乐天堂app下载 rest of us faltered; his matchless foundation in chemical science exploited with such creative flexibility. Twenty years ago we were 乐天堂app下载 three amigos who did 乐天堂app下载 click manifesto and a lot of really good, new and/or useful chemistry. We reunited recently to write a commentary for 乐天堂app下载 launch of Science Syn乐天堂app下载sis. What a pleasure! And Hartmuth is still 乐天堂app下载 kindest, perennially upbeat and happiest "happy chappy" I know.