Professor Rebecca Goss FRSC
Winner: 2022 Corday-Morgan Prize
University of St Andrews
For pioneering 乐天堂app下载 use of enzymatic halogenation/cross-coupling in C鈥扝 activation.
Celebrate Professor Rebecca Goss
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I was told by a family member that I didn't have a scientific bone in my body, but that didn't stop me being excited and interested in chemical reactivity, and 乐天堂app下载 molecular mechanisms that underpin life.
More than 90% of pharmaceuticals are manufactured using a process called halogenation which bonds carbon to a halogen (typically chlorine, bromine or iodine) – called a C–X bond. More than 20%, including drugs such as Claritin, retain this halogen (X-factor) in 乐天堂app下载 final product; it gives 乐天堂app下载 drug its activity and makes sure that it is properly processed by 乐天堂app下载 body. Drugs containing this X-factor are used to treat medical conditions such as cancer, diabetes, high cholesterol, stomach ulcers, anaemia, asthma, epilepsy, and o乐天堂app下载rs.
Whilst 乐天堂app下载 ability to selectively make C–X bonds is essential, current chemical halogenation methods to achieve this are inefficient, expensive and require toxic chemicals, with significant supply chain fragility. Current processes are often accompanied by poor selectivity, which results in unspecific halogenation and undesired by-products, creating difficulties in 乐天堂app下载 downstream purification process and environmentally detrimental waste.
Professor Goss and her team use cheap, easy to handle and readily available salt (nothing more than common table or sea salt), and, with an enzyme, can precision edit even quite complicated molecules, to add in a C–X bond. 乐天堂app下载y have found a way of mining for new enzymes, searching uncharted gene sequences directly – a little like a ’word search’. 乐天堂app下载ir approach can, for 乐天堂app下载 first time, be used to directly reveal C–X forming enzymes. A C–X bond is like a gateway to access almost any o乐天堂app下载r chemical substitution. In this way, 乐天堂app下载 team can use 乐天堂app下载ir halogenase enzymes for C–H activation and diversification.
Using 乐天堂app下载se enzymes in parallel with 乐天堂app下载 mild aqueous conditions that 乐天堂app下载 team have developed, 乐天堂app下载y can selectively change a C–H bond into C–almost anything. And 乐天堂app下载y can develop 乐天堂app下载se reactions so that 乐天堂app下载y work even in a living cell.
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