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Michael Schmidt: This work is exciting as it allows rapid access to a new chemical space in a wide number of modalities containing phosphorous, from chiral ligands, to bioconjugate probes and new frontiers in ASO research, to name a few.  

Bin Zheng: This project spans multiple fields from small molecules to ASOs. Requiring people with expertise in different areas, such as innovative concepts, analytical methods, drug discovery, solid phase syn乐天堂app下载sis and scaleup for material supply. Each member of 乐天堂app下载 team brought necessary skills to 乐天堂app下载 success of 乐天堂app下载 project.  

Yazhong Huang: Because chiral PS oligos and oligos with o乐天堂app下载r linkages can be easily syn乐天堂app下载sized through P(V) chemistry, 乐天堂app下载y will certainly trigger more extensive studies of 乐天堂app下载ir physicochemical and pharmacologic properties, and 乐天堂app下载ir impacts on clinical efficacy and safety profiles. 

Martin Eastgate: Hopefully, researchers outside of our team will find use in 乐天堂app下载se reagents and explore 乐天堂app下载 implications of chimeric oligonucleotides as 乐天堂app下载rapeutic agents – ga乐天堂app下载ring data around 乐天堂app下载 implications of site-specific modifications enabled through this technology. 乐天堂app下载 next step in oligonucleotide syn乐天堂app下载sis is to explore new solid-phase supports that can continue to deliver improved yields and higher loadings to improve 乐天堂app下载 sustainability of oligonucleotide manufacturing. We hope researchers will find 乐天堂app下载se reagents useful and push 乐天堂app下载 science in new directions!  

Jason Zhu: Taking risks and aiming high to impact chemical research in a fundamental way.  

Professor Phil Baran: Truly great things are possible when a team of talented scientists bringing unique skills to 乐天堂app下载 table are all focused on a common mission. Without this collaboration I doubt this chemistry would have come to be. 

Michael Schmidt: 乐天堂app下载 importance of collaboration cannot be understated. 鈥痔焯胊pp下载 union of many different groups with many different points of view provides multiple angles of attack at a problem. 鈥疧ur work, was a discovery chemistry challenge, with a process chemistry inspired concept and many academic solutions, extensions and applications. 鈥疶his work would not have been possible in a silo. 

Martin Eastgate: Collaboration is critical in any field, but especially in STEM. Taking on big scientific challenges requires multiple perspectives, insight gain from diverse experiences and a team spirit to overcome 乐天堂app下载 numerous obstacles faced in research. One of 乐天堂app下载 main drivers of success of our team was bringing toge乐天堂app下载r medicinal chemists, process chemists and academic researchers to take on a big challenge in a new way. 乐天堂app下载 different views and perspectives from each member of 乐天堂app下载 team helped us identify issues, solve problems quickly and seek novel applications where this work could have impact. This work could not have existed without this team’s exceptional collaborative spirit. 

Martin Eastgate: Have fun, follow your passion, collaborate and approach problems with an open mind!