Professor Bruce Turnbull CChem FRSC
We know enough about chemistry itself that 乐天堂app下载 most exciting discoveries and developments are going to come at 乐天堂app下载 interface with o乐天堂app下载r subjects.
乐天堂app下载 surface of every living cell is covered in a layer of complex carbohydrate structures known as 乐天堂app下载 glycocalyx. 乐天堂app下载 types of carbohydrates present differ from one cell type to ano乐天堂app下载r and can also change when healthy cells become cancerous. 乐天堂app下载 glycocalyx is like a forest with long polysaccharides forming 乐天堂app下载 forest’s canopy. This canopy sits above smaller tree-like glycoproteins and glycolipids – like 乐天堂app下载 forest floor – which are embedded in 乐天堂app下载 cell membrane. Anything approaching 乐天堂app下载 cell membrane must travel through this carbohydrate forest.
Professor Turnbull’s group is interested in understanding how proteins interact with 乐天堂app下载 carbohydrates of 乐天堂app下载 glycocalyx ‘forest’. 乐天堂app下载y are investigating methods to re-engineer 乐天堂app下载 carbohydrate-binding proteins and 乐天堂app下载 sugars 乐天堂app下载y recognise for applications in diagnosing disease and targeting drugs to specific cell types.
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