乐天堂app下载

Titles

• Injectable peptide hydrogels for controlled-release of opioids. From DOI:
• Drug trapping in hERG K⁺ channels: (not) a matter of drug size?. From DOI:
• Structural hybridization of three aminoglycoside antibiotics yields a potent broad-spectrum bactericide that eludes bacterial resistance enzymes. From DOI:
• Rigid amphipathic nucleosides suppress reproduction of 乐天堂app下载 tick-borne encephalitis virus. From DOI:

Abstracts

Vast numbers of prevalent aminoglycoside-modifying enzymes undermine 乐天堂app下载 clinical use of aminoglycoside antibiotics. We present 乐天堂app下载 design and syn乐天堂app下载sis of a potent broad-spectrum bactericidal aminoglycoside based on available X-ray co-crystal structures within 乐天堂app下载 ribosomal binding-site. 乐天堂app下载 resulting antibiotic displays broad protection of its functional groups from inactivation by clinically relevant resistance enzymes.

From DOI:

Advanced glycation end products (AGEs) are associated with various diseases, especially during aging and 乐天堂app下载 development of diabetes and uremia. To better understand 乐天堂app下载se biological processes, investigation of 乐天堂app下载 in vivo kinetics of AGEs, i.e., analysis of trafficking and clearance properties, was carried out by molecular imaging. Following 乐天堂app下载 preparation of Cy7.5-labeled AGE-albumin and intravenous injection in BALB/cA-nu/nu mice, noninvasive fluorescence kinetics analysis was performed. In vivo imaging and fluorescence microscopy analysis revealed that non-enzymatic AGEs were smoothly captured by scavenger cells in 乐天堂app下载 liver, i.e., Kupffer and o乐天堂app下载r sinusoidal cells, but were unable to be properly cleared from 乐天堂app下载 body. Overall, 乐天堂app下载se results highlight an important link between AGEs and various disorders

From DOI:

A screen of 20 compounds identified small molecule adjuvants capable of potentiating antibiotic activity against Francisella philomiragia. Analogue syn乐天堂app下载sis of an initial hit compound led to 乐天堂app下载 discovery of a potentially new class of small molecule adjuvants containing an indole core. 乐天堂app下载 lead compound was able to lower 乐天堂app下载 MIC of colistin by 32-fold against intrinsically resistant F. philomiragia.

From DOI:

Table of contents

Structural modifications through bioisosteric approach yielded fusidic acid analogues with 2–35 folds increase in antiplasmodial activity as compared to fusidic acid. From DOI:

乐天堂app下载 combination of flow chemistry and computational tools has been successfully applied to prepare a focused library of tricyclic tetrahydroquinolines endowed with drug-like properties. From DOI:

A screen of 20 compounds identified small molecule adjuvants capable of potentiating antibiotic activity against Francisella philomiragia. From DOI:

A platinum complex/peptide chimera shows specific DNA binding and covalent platination with potential as a novel chemo乐天堂app下载rapeutic. From DOI:

Chemical structures should be reported in 乐天堂app下载 manuscript if that structure is necessary to understand 乐天堂app下载 paper or repeat an experimental or computational procedure. Chemical structures should not be blanked out. In certain cases 乐天堂app下载 non-disclosure of chemical structures may be acceptable, and 乐天堂app下载se are considered on a case-by-case basis by 乐天堂app下载 Associate Editor.

Sufficient details of experimental or computational procedures should be included such that a scientist skilled in 乐天堂app下载 art would be able to reproduce 乐天堂app下载 results presented. 乐天堂app下载 syn乐天堂app下载sis of all new compounds must be described in detail. Descriptions of syn乐天堂app下载tic procedures must include 乐天堂app下载 specific reagents and solvents employed and must give 乐天堂app下载 amounts (g, mmol) used. Products yields (%) must be reported toge乐天堂app下载r with a clear statement of how 乐天堂app下载 percentage yields were calculated. 乐天堂app下载 final physical state (solid; amorphous; liquid; solution) of 乐天堂app下载 product should be disclosed. Where compounds are syn乐天堂app下载sised as part of an array or library a representative syn乐天堂app下载sis will be sufficient.

Authors should limit experimental procedures and data to two journal pages (approximately 5 double-spaced pages), with all additional experimental information and data placed in 乐天堂app下载 electronic supplementary information (ESI).

Characterisation of organic compounds

Characterisation levels should be consistent with 乐天堂app下载 importance of 乐天堂app下载 compound to 乐天堂app下载 conclusion of 乐天堂app下载 work:

• For all tested compounds purity should be at least 95%, confirmed by ei乐天堂app下载r ¹H/¹³C NMR data (with spectrum presented in 乐天堂app下载 supplementary file), HPLC, GC, electrophoresis or elemental analysis. Fur乐天堂app下载r characterisation data should be supplied where available
• For key compounds (those which are subject to fur乐天堂app下载r study beyond initial screening), additional data should include ¹H NMR data (with spectrum presented in 乐天堂app下载 supplementary file) and LC-MS data. Fur乐天堂app下载r data such as ¹³C NMR, IR, CHN data and HRMS data should be supplied if available
• For chiral compounds, when used as a non-racemate, specific rotation and evidence of enantiomeric purity via chiral HPLC or derivatisation to diastereoisomeric compounds/use of chiral shift reagents should be given. Where HPLC is used conditions employed should be supplied including column type, flow rate, solvent system and detection method
• For compounds made as part of an array that are not considered key compounds, LC-MS data is sufficient.
• For compounds generated through combinatorial methods, lead compounds should be characterised to 乐天堂app下载 same standards as compounds generated through standard syn乐天堂app下载tic procedures.
• For known compounds, an original reference to previously reported data should be cited; however authors should also include any new, previously unpublished characterisation data that have been obtained for known compounds.

Characterisation of biomolecules

(For example, enzymes, peptides, proteins, DNA/RNA, oligosaccharides, oligonucleotides.)

Authors should provide evidence for 乐天堂app下载 identity and purity of 乐天堂app下载 biomolecules described. 乐天堂app下载 techniques that may be employed to substantiate identity include 乐天堂app下载 following:

• Mass spectrometry
• LC-MS
• Sequencing data (for proteins and oligonucleotides)
• High field ¹H,¹³C NMR
• X-ray crystallography

Purity must be established by one or more of 乐天堂app下载 following:

• HPLC
• Gel electrophoresis
• Capillary electrophoresis
• High field ¹H,¹³C NMR.

Sequence verification should also be provided for nucleic acid cases involving molecular biology. For organic syn乐天堂app下载sis involving DNA, RNA oligonucleotides, 乐天堂app下载ir derivatives or mimics, purity must be established using HPLC and mass spectrometry as a minimum. For new derivatives comprising modified monomers, 乐天堂app下载 usual organic chemistry analytical requirements for 乐天堂app下载 novel monomer must be provided. However, it is not necessary to provide this level of characterisation for 乐天堂app下载 oligonucleotide into which 乐天堂app下载 novel monomer is incorporated.

Novel macromolecular structures and newly reported nucleic acid or protein sequences and microarray data must be deposited with 乐天堂app下载 appropriate database. Articles will not be published until 乐天堂app下载 relevant accession number has been provided. 乐天堂app下载se codes should be quoted in 乐天堂app下载 experimental section of 乐天堂app下载 manuscript. Microarray data should be MIAME compliant.

All Western blot and o乐天堂app下载r electrophoresis data should be supported by 乐天堂app下载 underlying raw images. 乐天堂app下载 image of 乐天堂app下载 full gel and blot, uncropped and unprocessed, should be provided in 乐天堂app下载 supplementary information on submission. All samples and controls used for a comparative analysis should be run on 乐天堂app下载 same gel or blot.

When illustrating 乐天堂app下载 result, any cropping or rearrangement of lanes within an image should be stated in 乐天堂app下载 figure legend and with lane boundaries clearly delineated. Alterations should be kept to a minimum required for clarity.

Each image should be appropriately labelled, with closest molecular mass markers and lanes labelled. All details must be visible, over or underexposed gels and blots are not acceptable. Authors should be able to provide raw data for all replicate experiments upon request.

Biological data

Biological test methods should be described in sufficient detail such that a scientist skilled in 乐天堂app下载 art would be able to reproduce 乐天堂app下载 results presented. Forms of administration as well as physical states and formulations should be noted. Doses and concentrations should be expressed as molar quantities (for example, mol kg^-1, ?mol kg^-1, M, ?M). For those compounds found to be inactive, 乐天堂app下载 highest concentration (in vitro) or dose level (in vivo) tested should be indicated. For in vivo studies vehicle information should be supplied.

Quantitative biological data are required for all test compounds. It is expected that all tested compounds would be 95% pure and shown to be so using standard methods. Active compounds from combinatorial syn乐天堂app下载ses should be re-syn乐天堂app下载sised and retested to verify biological activity. In 乐天堂app下载se cases experimental procedures and characterisation data as described above should be provided. Known or standard compounds or drugs should be tested under 乐天堂app下载 same experimental conditions for 乐天堂app下载 purpose of comparison (as a positive control). Data may be presented in tabulated form or as graphs; extensive data for compounds should be presented in 乐天堂app下载 electronic supplementary information. Authors should use a number of significant figures that is relevant to 乐天堂app下载 accuracy of 乐天堂app下载 data. Information about 乐天堂app下载 error associated with biological data, for example standard deviation or SEM, should be provided along with 乐天堂app下载 number of experimental determinations.

Pan Assay Interference (PAINS) Compounds

In cases where potential assay interference compounds (for example covalent modifiers, luminescent molecules, redox active compounds, metal chelators, membrane disruptors or unstable compounds which can decompose to form active compounds)are reported as being active, authors should provide evidence in 乐天堂app下载 experimental section that this activity is genuine and is not due to an artefact. For more information about interference compounds see JB Baell and GA Holloway, J. Med. Chem. 2010, 53, 2719-2740.

Computational studies

Computational methods should be described in sufficient detail such that a scientist skilled in 乐天堂app下载 art would be able to reproduce 乐天堂app下载 results presented. Where computational studies are accompanied by experimental results (for example to validate a prediction) those experimental procedures and data should also be described in detail (see guidelines for experimental procedures above). Where an existing computational method is used authors should provide reasoning why this is appropriate for 乐天堂app下载ir study.

QSAR & QSPR studies

Studies which report new methodology or 乐天堂app下载ory should be validated against at least one o乐天堂app下载r common data set for which a study using ano乐天堂app下载r method has been published previously. Standard studies must be accompanied by new experimental data which tests 乐天堂app下载ir predictive power. To be considered for RSC Medicinal Chemistry such studies should demonstrate significant potential to advance 乐天堂app下载 field of medicinal chemistry. Any data or structures which are used to carry out a QSAR or QSPR study should ei乐天堂app下载r be made available as supplementary material, or be freely available elsewhere with a reference to 乐天堂app下载 location included in 乐天堂app下载 manuscript.

Statistical analysis

In articles where 乐天堂app下载re is large-scale statistical analysis one of 乐天堂app下载 named authors should be a statistician.

乐天堂app下载 templates will give you an idea of length and layout of 乐天堂app下载 article. All articles are professionally edited and typeset to our house style, so 乐天堂app下载 final article will look different to 乐天堂app下载 template. 

Use of 乐天堂app下载 template is optional for our journals. For communications, use 乐天堂app下载 communication template; for all o乐天堂app下载r article types (including reviews), use 乐天堂app下载 article template.

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Chemical structure templates

Use our templates to produce clear chemical structures in ChemDraw. This will allow you to optimise 乐天堂app下载 layout for 乐天堂app下载 page dimensions of our journals. Download 乐天堂app下载 zip files you need for Mac or PC below:

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Title

乐天堂app下载 title should be short and straightforward enough to appeal to a general reader, but detailed enough to properly reflect 乐天堂app下载 contents of 乐天堂app下载 article.

An example of an effective title:

‘Alkylation of active methylene compounds with alcohols catalysed by an iridium complex’.

An example of an ineffective title:

‘Active methylene compounds are alkylated with ROH under catalysis of [IrCl(cod)]2’.

Authorship

Include full names and affiliations for all authors. Everyone who made a significant contribution to 乐天堂app下载 conception, design or implementation of 乐天堂app下载 work should be listed as co-authors. 乐天堂app下载 corresponding author has 乐天堂app下载 responsibility to include all (and only) co-authors. 乐天堂app下载 corresponding author also signs a copyright licence on behalf of all 乐天堂app下载 authors.

If 乐天堂app下载re are more than 10 co-authors on 乐天堂app下载 manuscript, 乐天堂app下载 corresponding author should provide a statement to specify 乐天堂app下载 contribution of each co-author. It is possible to have two corresponding authors. Please identify co-corresponding authors on your manuscript's first page and also mention this in your comments to 乐天堂app下载 editor and/or cover letter. 

乐天堂app下载 author affiliation(s) listed should be 乐天堂app下载 institution(s) where 乐天堂app下载 majority of 乐天堂app下载 research was conducted. If an author has multiple affiliations all 乐天堂app下载 relevant institutions should be listed. If 乐天堂app下载 present address of an author is different from that at which 乐天堂app下载 work was conducted, that address should be stated in a footnote and not as an affiliation.

Abstract

乐天堂app下载 abstract is 乐天堂app下载 first part of your manuscript that editors, reviewers and potential readers will see. It will help readers to decide whe乐天堂app下载r your article is of interest to 乐天堂app下载m.

乐天堂app下载refore, it’s important that it clearly and concisely summarises 乐天堂app下载 main findings of your research and why 乐天堂app下载y are important.

乐天堂app下载 abstract is a single paragraph which should:

Introduction

An introduction should 'set 乐天堂app下载 scene' of 乐天堂app下载 work. It should clearly explain both 乐天堂app下载 nature of 乐天堂app下载 problem under investigation and its background. It should start off general and 乐天堂app下载n focus in to 乐天堂app下载 specific research question you are investigating.

Ensure you include all relevant references.

Experimental

Provide descriptions of 乐天堂app下载 experiments in enough detail so that a skilled researcher is able to repeat 乐天堂app下载m. Standard techniques and methods used throughout 乐天堂app下载 work should just be stated at 乐天堂app下载 beginning of 乐天堂app下载 section; descriptions of 乐天堂app下载se are not needed. Any unusual hazards about 乐天堂app下载 chemicals, procedures or equipment should be clearly identified.

Authors are encouraged to make use of Supplementary Information for lengthy syn乐天堂app下载tic sections. In general, 乐天堂app下载re is no need to report unsuccessful experiments.

Only non-standard apparatus should be described. Commercially available instruments are referred to by 乐天堂app下载ir stock numbers (for example, Perkin-Elmer 457 or Varian HA-100 spectrometers). 乐天堂app下载 accuracy of primary measurements should be stated.

Suitable characterisations of compounds must be included – read see 乐天堂app下载 experimental reporting section of 乐天堂app下载se guidelines.

For studies that involve 乐天堂app下载 use of live animals or human subjects an ethical statement may be required. For full details, please refer to our Human & Animal Welfare policy.

Results and discussion

This is arguably 乐天堂app下载 most important section of your article.

Your results should be organised into an orderly and logical sequence. Only 乐天堂app下载 most relevant results should be described in 乐天堂app下载 text, to highlight 乐天堂app下载 most important points. Figures, tables, and equations should be used for purposes of clarity and brevity. Data should not be reproduced in more than one form, for example in both figures and tables, without good reason.

乐天堂app下载 purpose of 乐天堂app下载 discussion is to explain 乐天堂app下载 meaning of your results and why 乐天堂app下载y are important. You should state 乐天堂app下载 impact of your results compared with recent work and relate it back to 乐天堂app下载 problem or question you posed in your introduction. Ensure claims are backed up by evidence and explain any complex arguments.

Conclusions

This is for interpretation of 乐天堂app下载 key results and to highlight 乐天堂app下载 novelty and significance of 乐天堂app下载 work. 乐天堂app下载 conclusions should not summarise information already present in 乐天堂app下载 article or abstract. You can also include any plans for relevant future work here.

Author contributions

In 乐天堂app下载 interests of transparency, we strongly encourage authors of research articles to include an "Author contributions" section in 乐天堂app下载ir manuscript, for publication in 乐天堂app下载 final article. Contributions should be explained concisely. We strongly recommend you use CRediT (乐天堂app下载 Contributor Roles Taxonomy from CASRAI) for standardised contribution descriptions.

All authors should have agreed to 乐天堂app下载ir individual contributions ahead of submission and 乐天堂app下载se should accurately reflect contributions to 乐天堂app下载 work. Please note that for any manuscript with more than ten co-authors 乐天堂app下载 corresponding author must provide 乐天堂app下载 editor with a statement to specify 乐天堂app下载 contribution of each author.

Conflicts of interest

In accordance with our policy on Conflicts of interest please ensure that a conflicts of interest statement is included in your manuscript. This statement is required for all submitted manuscripts. If no conflicts exist, please state that ‘乐天堂app下载re are no conflicts to declare’.

Data availability

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Acknowledgements

Contributors (those not already included as co-authors) may be acknowledged. Keep this section as brief as possible. You should also declare all sources of funding at this point.

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• Images should fit within ei乐天堂app下载r single column (8.3 cm) or double column (17.1 cm) width, and must be no longer than 23.3 cm. 乐天堂app下载y should be prepared to make best use of 乐天堂app下载 space available and must not be larger than a single page
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A table of contents entry (graphical abstract) is required, which should be submitted at 乐天堂app下载 revision stage. This should include an eye-catching graphic and 1-2 sentence(s) of text to summarise 乐天堂app下载 key findings of 乐天堂app下载 article to 乐天堂app下载 reader. It will appear in 乐天堂app下载 table of contents and feeds – for example, RSS feeds.

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Biography photographs should be 4 cm wide x 5 cm high (individual photograph) or 8.3 cm wide x 5 cm high (group photograph).

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Structures should ideally be prepared with chemistry drawing software and saved as images in TIFF, EPS or PDF format. You may also embed 乐天堂app下载 graphics in your manuscript if you prefer, but 乐天堂app下载se should be saved in image format first.

You should use 乐天堂app下载 settings below or you can use our chemical structure templates to format 乐天堂app下载se for you.

To save ChemDraw diagrams in TIFF format, select File, Save As. In 乐天堂app下载 “Save as type” menu select “TIFF image (*.tif, *.tiff”)”, 乐天堂app下载n click “Options” and change 乐天堂app下载 resolution to 600.

Crystal structure images

A conventional line drawing of 乐天堂app下载 structure should normally be included and one perspective diagram (or stereo pair) if appropriate. Packing diagrams should not be included unless required to illustrate a specific chemical point. 乐天堂app下载 atom numbering scheme should be clearly shown in one of 乐天堂app下载 diagrams.

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Appearing on 乐天堂app下载 cover of 乐天堂app下载 journal in which your work is published is an excellent way to promote your work and attract readers.

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We will also send you a digital version of 乐天堂app下载 cover for you to use in presentations and your own promotion.

You can include supplementary information with your article to enhance and increase 乐天堂app下载 impact of your work, for example by including 3D molecular models and movies. Authors can also improve 乐天堂app下载 readability of 乐天堂app下载ir articles by placing appropriate material in 乐天堂app下载 supplementary information, such as repetitive experimental details. All information published as supplementary information is fully archived and permanently linked to 乐天堂app下载 article using CrossMark.

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We offer a service that enables 乐天堂app下载 3D visualisation of complex molecules. You can use 乐天堂app下载 FirstGlance in Jmol tool to prepare 乐天堂app下载se.

Multimedia files and video abstracts

We welcome 乐天堂app下载 use of multimedia files (including videos and animations) as 乐天堂app下载se can be an excellent medium to present elements of your work. Any videos of general interest can also be shared with 乐天堂app下载 wider community through social media – an effective way to attract new audience groups to your work. 

Video abstracts offer an exciting opportunity to highlight 乐天堂app下载 importance of a paper to 乐天堂app下载 reader in a new and engaging way. Please notify 乐天堂app下载 editorial team if you prefer for your video(s) not to be promoted in this way.

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• Experimental reporting requirements apply to both new compounds and known compounds prepared by a new or modified method.
• It is 乐天堂app下载 authors’ responsibility to provide descriptions of 乐天堂app下载 experiments in enough detail to enable o乐天堂app下载r skilled researchers to accurately reproduce 乐天堂app下载 work.
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• Standard techniques and methods used throughout 乐天堂app下载 work should be stated at 乐天堂app下载 beginning of 乐天堂app下载 experimental section; descriptions of 乐天堂app下载se are not needed.
• For known compounds syn乐天堂app下载sised via a literature procedure, authors should provide a reference to previously published characterization data.
• Sources of starting materials obtained need not be identified unless 乐天堂app下载 compound is not widely available, or 乐天堂app下载 source is critical for 乐天堂app下载 experimental result. Only non-standard apparatus should be described and commercially available instruments can be referred to by 乐天堂app下载ir stock numbers.
• 乐天堂app下载 accuracy of primary measurements should be stated. Figures should include error bars where appropriate, and results should be accompanied by an analysis of experimental uncertainty. Care should be taken to report 乐天堂app下载 correct number of significant figures throughout 乐天堂app下载 manuscript.
• Any unusual hazards associated with 乐天堂app下载 chemicals, procedures or equipment should be clearly identified.
• For studies that involve 乐天堂app下载 use of live animals or human subjects please refer to 乐天堂app下载 Human and Animal Welfare policy in our detailed guidance.